3 0 obj Species-dependent variations in the in vitro myotoxicity of death adder (Acanthophis) venoms. Seram. 2009; 16:1473-7.
Cells were lifted using trypsin, and pelleted. Renal damage can be induced by direct and indirect myotoxic effects of toxins. Queen Saovabha Memorial Institute, The Thai Red Cross Society, Many studies have reported the occurrence of lethal acute renal failure after snakebites, (Malayan krait) is a medically important venomous snake distributed widely throughout Southeast, g/kg bodyweight. 4a and b).
2013;112(5):325–34. b) The horse antiserum immunologically reacted with and neutralized the lethal effects of both the homologous and the 16 heterologous Asian/African elapid venoms tested.
"H" represents hyaline cast. Handling: The banded and Malayan blue kraits are not known to bite during the daytime. β-Cardiotoxin: a new three-finger toxin from Ophiophagus hannah (king cobra) venom with beta blocker activity. PLoS One. Toxins (Basel). 6. The cytotoxic effects of Malayan krait venom were determined using human embryonic kidney (HEK-293) cells. internal
Plasma lactate dehydrogenase (LDH) and, creatine phosphokinase (CPK) were determined by, immunoturbidimetric assay using Cobas Integra 800. stPart In brief, venoms (25 μL) were loaded on to a 96-well plate in triplicate, then 200 μL reagent buffer mix was added to each well. MC, KW, MRAR, WCH, and JC wrote the manuscript. Renal blood flow, glomerular filtration rate, renal fraction and the rate of urine flow were decreased 24 hr after venom injection and rose to the control levels at 48 hr. Mongkon Charoenpitakchai PDF/A ID Schema Biochem Pharmacol. Toxicon. Snakebite is a public health problem in rural, tropical and subtropical regions with more than 85,000, deaths and 150,000 permanent sequelae worldwide, (Malayan krait) is an important venomous snake, recovery has been observed in neurotoxic snakebite, following respiratory and other supportive treatment, without antivenom administration [3, 4].
internal Specifies the types of editor information: name and ORCID of an editor. B. candidus envenomed patients in Vietnam were reported to display symptoms of rhabdomyolysis and serum CK level elevation . Clinically, neurotoxicity is the most signiﬁcant manifestation following Malayan krait envenoming, which has been attributed to the presence of pre- and post-synaptic neurotoxins in the venom … In the kidneys, the presence of hyaline cast was seen in renal tubules after 3 h venom administration. This simple strategy and procedure could be readily adapted for the production of pan-specific antisera against elapids of other continents. J Vis Exp. Res V. Cresolpthalein complexone method. The occurrence of rhabdomyolysis and increased serum CK levels following krait envenoming have been reported in cases involving Vietnamese B. multicinctus and B. candidus. 2017;133:95–102.
Plasma renin activity was also measured by the radioimmunoassay. Interestingly, BC-S venom significantly decreased plasma sodium levels, which suggests hyponatremia. For treatment period, envenomation, was performed by intravenous injection of, venom (1 mg of lyophilized venom dissolved in 1 mL, of 0.9 % saline solution) at a dosage of 50, bodyweight. Morphological changes (H&E stain; 400× magnification) of rat kidneys following intramuscular administration of (a) vehicle control and (b) BC-NE venom for 3 h. Morphological changes (PAS stain; 400× magnification) of rat kidneys following intramuscular (i.m.) http://ns.adobe.com/pdfx/1.3/ 2007; 35: 659-62. Basic Clin Pharmacol Toxicol. through activation of the sympathetic nervous system. Curr Pharm Des. name 2005;46(4):363–70.
WCH, CR, SM and JC developed the idea for the study. CAS A marked elevation in LDH levels (> 3500 U/L) was seen following venom administration at 24 h (n = 4–5, p < 0.05, one-way ANOVA, followed by Bonferroni t-test, Fig. A pharmacological examination of the cardiovascular effects of Malayan krait (Bungarus candidus) venoms. Hart AJ, Smith AI, Reeve S, Hodgson WC. Data on epidemiology, examination findings, snake identification, treatment, antivenom dose and complications were collected.
Envenomed animals showed a reduction in renal fraction, while renal vascular resistance stepwise increased. GTS_PDFXVersion The plasma LDH level increased from 124.7. weighing 2.5-3.5 kg were used. Methods: Twelve adult male New Zealand white rabbits were used to study the effect of B. candidus venom on general circulation and renal hemodynamics. Bungarus candidus (Malayan krait) is a medically important venomous snake distributed widely throughout Southeast Asia. Toxicon.
A reference to the original document from which this one is derived. Kini RM, Arni RK. (a) Plasma lactate dehydrogenase (LDH) and (b) plasma creatine kinase (CK) levels at 3, 6 and 24 h following intramuscular (i.m.) Specifies the types of series editor information: name and ORCID of a series editor. Preliminary experiments examined the effects of BC-S and BC-NE venoms, administered to three rats, in intramuscular (i.m.) Untreated severe myonecrosis may cause morbidity and mortality. Correspondence to Pharmacol Ther. into the right hind limb. The hypotensive action of PLA2 fractions was not affected by heat treatment (70-80 degrees C, 30 min, pH 6.8). venom on cardiovascular function in rabbits. Membrane depolarization is the initial action of crotoxin on isolated murine skeletal muscle. Editor information: contains the name of each editor and his/her ORCID identifier. Oguiura N, Boni-Mitake M, Rádis-Baptista G. New view on crotamine, a small basic polypeptide myotoxin from south American rattlesnake venom. It has been reported that Bucain, isolated, the cardiac tissue as a dose-dependent decrease in, heart rate without affecting contractility .