Can Javon Kinlaw replace DeForest Buckner right away? The 49ers pass rush has a field day against a rebuilding offensive line. This game won't be a cakewalk for San Francisco, as the league's top-ranked pass defense from 2019 will be tested against the Cardinals' new-look pass offense (which includes DeAndre Hopkins). Courtesy of William Hill Sports Book, we'll provide over/under win totals for every opponent along with lines for Week 1 and Week 2. San Francisco just has a clear advantage in this matchup. 2 ranked defense in 2019, including the entire secondary from the No. Saints 27-24, Prediction: The 49ers will get vengeance against a Rams team that beat them at home in Week 6, also known as the game Mostert runs for over 150 yards and collects a pair of touchdowns. LAC. 49ers 24-20, Prediction: The 49ers head for the first of many East Coast trips this season, playing at MetLife Stadium on back-to-back weeks. The latest news, video, standings, scores and schedule information for the San Francisco 49ers San Francisco lost Emmanuel Sanders in free agency, but selected Brandon Aiyuk with the No. The San Francisco 49ers will go from disappointed NFC champions in Super Bowl 54 against the Chiefs to missing the playoffs in 2020. section: | slug: | sport: football | route: team_page_schedule_by_season | 25 overall pick in the draft and signed Travis Benjamin. This one could get ugly in a hurry, especially on a short week. Kittle scores a late touchdown to keep the 49ers unbeaten. The Seahawks having a healthy contingent at running back will help Wilson and the pass offense, especially with big play wideouts like Tyler Lockett and D.K. Get the day's big stories + fun stuff you love like mock drafts, picks and power rankings. How good (or bad) the Patriots will be is anyone's guess, which makes this game so intriguing. Printable 2020-21 San Francisco 49ers Schedule. Our external data provider is experiencing technical problems that are impacting this page. 49ers 20-14, Prediction: After that brutal five-team gauntlet San Francisco just faced, it will be nice for the 49ers to get a rebuilding team in the Redskins. amzn_assoc_marketplace = "amazon"; New England already has seen its schedule shifted around several times due to COVID-19, as the team's game Sunday against the Denver Broncos was pushed from Week 5 after defensive tackle … 1 running back with Tevin Coleman inserted as the No. This page will be updated as soon as the issue is resolved. Breida will be looking for vengeance against his former team as Miami will look to use his speed for big plays against the 49ers defense that is starting to round into form. San Francisco's pass catchers will struggle against Los Angeles' secondary, as Garoppolo will have his first bad game of the year. Let's not forget Kyler Murray will be coming into his own as a quarterback. 49ers 34-21, Prediction: This will be a tough game for the 49ers, but the Bills also face one of their biggest tests of the season in heading to San Francisco.